Class 18 Drugs 2008 upload

Class 18 Drugs 2008 upload - Some Drugs of Addiction...

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Some Drugs of Addiction November 6, 2008
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Outline What is addictive behavior? Dopamine and the pleasure principle Nicotine Alcohol Cocaine Methamphetamine If Time - Ecstacy Much of this information has been obtained from studies at Brookhaven National Laboratories.
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Addictive drugs and their effects on the brain Cocaine Alco Nicotine Amphetamines Heroin Marijuana Solvents Ecstasy www.nida.nih.go
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Dopamine addiction movement well-being novelty-seeking
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Dopamine With few exceptions, drugs of abuse elevate brain dopamine The environment plays a crucial role in addiction and relapse
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2. Pleasure, addictive system. The VTA is activated by addictive behavior, even the initial stages of ‘madly in love’ 1. Motor control system: Affected in Parkinson’s Disease Also involved in schizophrenia s:
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Nicotine and Smoking www.peakofhealth.ch/smoking.html
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The three neural output systems of the CNS make nicotinic ACh synapses ACh nicotinic ACh nicotinic ACh nicotinic Nicotinic receptors are the in brain, somatic and autonomic NS
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General effects of nicotine Nicotine increases activation of skeletal muscle. Nicotine mimics the sympathetic nervous system by causing a release of nor-epinephrine. The effect on the sympathetic nervous system over rides the effect on the parasympathetic. The addictive properties of nicotine are due to an increase of dopamine in the brain. Small, rapid doses lead to alertness and arousal Long, drawn out doses – sedation and relax
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Effects of smoking on MAO B (PET)
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Dopamine neurons are inhibited by GABA Nicotine reduces this inhibitory control The result in an increase in dopamine release The link is an increase in the endocannabinoids (ECBs)
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Imaging effects of cigarettes on the human brain Smoking reduces one of the enzymes that controls the concentration of dopamine in brain non-smoker smoker
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Cancer Heart Disease Vascular Disease Aneurysm Loss of Brain Enzymes, MAOA and B Loss of Brain Enzymes, MAOA and B Appetite suppression
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Class 18 Drugs 2008 upload - Some Drugs of Addiction...

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