Class 19 Cannabinoids upload

Class 19 Cannabinoids upload - Cannabis miracle drug? Fact...

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Cannabis – miracle drug? Fact or Fiction Class 19 November 11, 2008
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Suggeted websites www.marinol.com/ slides.html (Website with animated lecture) www.acompliareport.com/ Endocannabinoid.htm http://www.druglibrary.org/schaffer/Library/studies http://scienceblogs.com/corpuscallosum/2007/07/ (this site describes the problems with acomplia)
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Outline Marijuana background Endocannabinoids in the brain Therapeutic potential Appetite control and nicotine addiction Role in fertility
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Ancient Egypt Persia
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Ancient Cultures and Marijuana China ~ 2500 B.C. Egypt ~ 2000 B.C. Middle east ~ 1500 B.C. India ~ 1000 B.C. Persia, Greece, Rome, Sub-Saharan Africa Most common use was to relieve pain, reduce inflammation and as a sedative.
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Post 1600 Law to grow hemp in Jamestown (1619) Napoleon returns with cannabis seeds from Egypt (1799) 1850 >8000 cannabis plantations in US 1850-1890 – most widely prescribe med 1895 – word ‘marijuana’ by Pancho Villa 1850 onward – medical use declines, image suffers. WHY?
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Decline of Cannabis Biomedical use was replaced by more effective drugs. Gained reputation as an intoxicant Utah in 1915 – first anti-cannabis law Followed by Texas, UK, Canada and US Used by JFK for back pain (fired UN rep) 1970 - Schedule 1 drug – no medicinal value; highest addictive potential Despite numerous reports of benefits and low toxicity, cannabis remains a TABOO.
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Marijuana; problem medicine Difficult to administer in reliable dose Fat soluble, water insoluble Cannot separate psychotropic effect from medicinal (problem of designer drug). Side effects of smoking out-way therapeutic value. Existing drugs are more effective, To control glaucoma – 20 joints/day Zofran and compazine better for nausea Opiates and NSAIDs better for pain
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Drug Fatalities * (1997-2005) from FDA 1 °+ 2° = Total Marijuana - 0 + 279 = 279 Zofran - 79 + 76 = 155 Baclofen - 72 + 33 = 105 Neurontin - 968 + 302 =
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Class 19 Cannabinoids upload - Cannabis miracle drug? Fact...

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