Sp09 BIO 202 Ch17 part 3 mutations

Sp09 BIO 202 Ch17 part 3 mutations - Chapter 17 From Gene...

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Click to edit Master subtitle style 7/17/09 Chapter 17 From Gene to Protein Part 3: Mutations
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7/17/09 Cancers occur with different frequencies in different human populations Over a human lifetime, ~1016 cells are formed. Each has the potential to give rise to a tumor, should disaster strike. Of the ~100 types of cancers, some occur with comparable frequencies (incidence) in various human populations, while the frequencies of other cancers vary widely. Obvious factors contributing to variable cancer incidence are genetics and environment Genetics: variable frequency of cancer susceptibility alleles in different populations
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7/17/09 Figure 2.20 The Biology of Cancer (© Garland Science 2007) Studies of cancer rates in migrant populations minimize genetic component Japan
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7/17/09 Figure 11.2 The Biology of Cancer (© Garland Science 2007)
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7/17/09 Figure 12.20a
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7/17/09 Figure 20-3 Molecular Biology of the Cell (© Garland Science 2008)
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7/17/09 Figure 20-11 Molecular Biology of the Cell (© Garland Science 2008)
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7/17/09 Figure 12.17 (1)
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7/17/09 Figure 12.17 (2)
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7/17/09 Figure 12.17 (3)
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7/17/09 Figure 2.22 The Biology of Cancer (© Garland Science 2007) Carcinogenic (in lab mice) hydrocarbons found in coal tar, result from incomplete combustion of organic compounds.
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7/17/09 Figure 2.25 The Biology of Cancer (© Garland Science 2007) Mutagenicity in bacteria correlates with tumorigenicity in lab mice Tumors in mice Mutations in DNA (bacteria)
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7/17/09 Mutations: DNA damage Point mutations: substitutions Insertions and deletions Reciprocal translocations
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7/17/09 Point mutations can affect protein structure and Mutations are changes in the genetic material of a cell or virus Point mutations are chemical changes in just one base pair of a gene The change of a single nucleotide in a DNA template strand leads to production of an abnormal protein
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Click to edit Master subtitle style 7/17/09 LE 17-23 Wild-type hemoglobin DNA mRNA 3 5 5 3 5 3 3 5 Mutant hemoglobin DNA mRNA Normal hemoglobin Sickle-cell hemoglobin
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7/17/09 Types of Point Mutations Point mutations within a gene can be divided into two general categories Base-pair substitutions Base-pair insertions or deletions
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This note was uploaded on 07/16/2009 for the course BIO 202 taught by Professor Dean during the Spring '08 term at SUNY Stony Brook.

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Sp09 BIO 202 Ch17 part 3 mutations - Chapter 17 From Gene...

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