BiomaterialsResearch-01

BiomaterialsResearch-01 - EBM 105 E Bi om er i al s at...

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EBME 105: EBME 105: Bi omat er i al s Bi omat er i al s November 16, 2007 November 16, 2007 Desi gn and Summar y Desi gn and Summar y Christopher J. Hernandez Christopher J. Hernandez Glennan 615A Glennan 615A ([email protected]) ([email protected])
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Mechanical Adaptation in Bone Culmann and von Meyer 1867
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Hart 1983
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Mechanical Adaptation Carter 1982, Frost 1987
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Mechanical Adaptation Beaupré et al. 1990
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Mechanical Adaptation Beaupré et al. 1990
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Mechanical Adaptation Will bone be lost around implants? Which implant design is best? Laboratorio di Tecnologia Medica, ISTITUTI ORTOPEDICI RIZZOLI
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Adapted from Hernandez et al. 2000
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Mechanical Engineering-Biomechanics Interactions Topological Optimization Given a mechanical need, what is the optimal shape?
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Biomechanics of Osteoporosis Osteoporosis Reduced bone mass 10-44 Million Americans Hip fracture more common than uterine, ovarian and breast cancer combined National Osteoporosis Foundation (2004) Dempster et al. 1986
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Biomechanics of Osteoporosis DXA based Bone Mineral Density (BMD, g/cm 2 ) Areal Measurement Explains up to 80% of bone strength Bouxsein et al. (1995) Is an indicator of future fracture risk Wasnich and Miller (2000) Bone Mass Loads Fracture
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Fractures More than half of of fractures occur in patients with BMD > osteoporosis threshold Schuit et al. (2004) 7806 patients
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Bone Quality 2005 NIAMS/ASBMR Meeting NIAMS 2006-09 Plan: “Define bone quality and the methodology for measuring it.”
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What is Bone Quality?
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