Introduction-Fischer - carboxylic acid, isoamyl as our...

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Introduction In a Fischer esterfication reaction, an ester is synthesized by an acid catalyzed substitution reaction between an alcohol and a carboxylic acid. The carbonyl oxygen is protonated by the acid catalyst which initiates the nucleophilic attack by the alcohol on the carbonyl carbon to create a tetrahedral intermediate. Transfer of a proton from one oxygen to another yields a second tetrahedral intermediate. Then it converts the hydroxyl group into a good leaving group. A proton is lost and the expulsion of water regenerates the acid catalyst and also produces the ester product. We will be using acetic acid as our
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Unformatted text preview: carboxylic acid, isoamyl as our alcohol, and sulfuric acid as our catalyst. Mechanism- attached Table of reagents Name Melting Point (C) Boiling Point (C) Density g/ mL Molecular Weight g/ mol Structure Acetic Acid 16.6 117.9 1.05 60.05 Anhydrous Sodium Sulfate 884 n/a 2.68 142.04 Isoamyl Alcohol 117.2 132 0.809 88.17 Sodium Bicarbonate 270 851 2.159 84.01 Sulfuric Acid 3.0 280 1.84 98.09 Isoamyl acetate-78 142 0.88 130.19 Safety Wear goggles, gloves, and proper clothing to prevent skin exposure....
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This note was uploaded on 07/19/2009 for the course CHEM 234-54 taught by Professor Morrison during the Spring '09 term at University of Georgia Athens.

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