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Introduction-Witting

Introduction-Witting - r Weight g/mol Structure...

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Introduction The Witting reaction is a nucleophilic addition reaction between phosphorus ylide and an aldehyde or a ketone, which yields an alkene. An ylide is a neutral, dipolar compound that has adjacent +/- charges. A phosphorus ylide can be prepared by an SN2 reaction involving a primary (sometimes secondary) alkyl halide with triphenylphosphine, followed by a treatment with a base. We will be creating an alkene product from a phosphorous ylide (benzyltriphenylphosphonium chloride). The aldehyde we are using is 9-anthraledehyde. Mechanism
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Table of Reagents Name Melting Point (ºC) Boilin g Point (ºC) Density g/mL Molecula
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Unformatted text preview: r Weight g/mol Structure 1-propanol-126 97.2 0.803 60.10 9-anthraldehyde 103-105 n/a n/a 206.24 Benzyltriphenylphosph onium chloride 323-332 n/a n/a 388.88 Calcium Chloride 782 1600 n/a 110.99 CaCl 2 Dichloromethane-96.7 39.0 1.326 84.93 Sodium hydroxide 318 1390 2.10 40.00 NaOH Water 100 1.00 18.02 9-(2-phenylethenyl) anthracene 131-133 n/a n/a 280.36 Safety Sodium Hydroxide should be handled carefully. It is a strong base and can cause skin damage and eye damage Triphenylphosphine oxide (byproduct of the Witting Reaction) should be handled carefully. It is toxic and can be absorbed through the skin....
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