L4-Transport into ER - BIO320S - Lecture 4 Cell...

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BIO320S - Lecture 4 Cell Compartments Membrane Traffic: The Secretory Pathway, The RER, Signal Peptides, Membrane Proteins
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There Are Numerous Membrane-Bound Organelles in Eukaryotic Cells Proteins Must Be Specifically Sorted to Each Organelle What determines the identity of an organelle? How is organelle-specific protein and lipid composition achieved? Alberts 12-1
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QuickTime™ and a Animation decompressor are needed to see this picture. What happens after Translation? Protein Folding Sorting to a Compartment mRNA-> from Molecular Cell Biology
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What is required for protein sorting?  A signal (address), intrinsic to the protein A receptor that recognizes the signal and directs it to the correct membrane A translocation machinery Energy to transfer the protein to its new place
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Two General Types of Protein Sorting Signals
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Do not memorize ALL these
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Necessary: It is required to sort the protein to its specific compartment. It cannot be deleted or changed in amino acid sequence. Sufficient: It is the only portion of a protein required to sort it to a specific compartment It usually interacts specifically with a binding partner/receptor Some signals are removed from the protein upon arrival to the target location. Some are not Common properties of a sorting signal
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Most Common Protein Sorting Pathways Alberts 12-6
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L4-Transport into ER - BIO320S - Lecture 4 Cell...

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