L9-Nuclear Transport - BIO320 - Lecture 9 NUCLEAR TRANSPORT...

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BIO320 - Lecture 9 NUCLEAR TRANSPORT Optional Reading on Blackboard Science (2006) 314: 766-767
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The Nucleus may have originated by invagination of the Plasma  Membrane in early Eukaryotic Cells This model explains the relationship between the Nucleus and the  Secretory membranes Alberts 12-4
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Alberts 12-8 The structure of the Nuclear Membrane
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Alberts 12-19 The Nuclear Lamina gives support to the Nuclear Membrane Made from Intermediate Filaments
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Free diffusion Ions, ATP, small proteins <50 kDa mRNAs tRNAs Shuttling proteins Nuclear proteins Ribosomal proteins Ribosomal subunits Many proteins and RNAs are transported in/out of the nucleus
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The NPC is a selective gate for traffic into the nucleus < ~50 kDa > 50 kDa Alberts 12-10
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Structure of the nuclear pore complex (NPC) > 30 times the size of a ribosome! Alberts 12-9
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A New Model of the Channel within the Nuclear Pore The Nuclear Pore contains many proteins called nucleoporins that fill the channel forming a gel that excludes large proteins.
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L9-Nuclear Transport - BIO320 - Lecture 9 NUCLEAR TRANSPORT...

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