L9 Outline - BIO 320 CELL BIOLOGY Summer 2009 A. De Lozanne...

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BIO 320 - CELL BIOLOGY – Summer 2009 A. De Lozanne Lecture 9 Nuclear Transport Reading: Alberts, 5th Ed. Pages 695-712 the following sections: The Compartmentalization of Cells All Eukaryotic cells have the same basic set of… Evolutionary origins explain the topological relationships of organelles. Proteins can move between compartments in different ways Gated Transport Transmembrane Transport Vesicular Transport Signal Sequences direct proteins to the correct cell address. Most organelles cannot be constructed de novo… Panel 12-1 Approaches to studying signal sequences The Transport of Molecules between Nucleus and Cytosol Nuclear pore complexes perforate the nuclear envelope Nuclear localization signals direct nuclear proteins to the nucleus Nuclear import receptors bind nuclear localization signals… Nuclear export works like nuclear import but in reverse. The Ran GTPase drives directional transport… Transport between the nucleus and cytosol can be regulated… During mitosis the nuclear envelope disassembles.  Outline I. General Aspects of Protein Sorting A. Proteins encoded by nuclear genes may have localization signals. B. The localization signal is a specific peptide sequence within the sequence of the entire protein. C. In the absence of a localization signal the protein will remain in the cytosol. D. The sequence of the localization signal is different for different compartments. E. Proteins can have more than one localization signal. F. Protein sorting occurs by specific pathways.  G. Localization signals are recognized by specific protein receptors. H. Proteins with appropriate signals are targeted for uptake into specific organelles I. Further sorting can occur within a compartment to segregate proteins. I. The Structure and Function of the Nuclear Pore Complex A. 1. moved into nucleus across the nuclear envelope  1
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L9 Outline - BIO 320 CELL BIOLOGY Summer 2009 A. De Lozanne...

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