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Unformatted text preview: A C B TS 1 TS 2 The overall rate of A C is controlled by step 1 which is the rate-determing step . slow step Note: A chemical intermediate , such as B, is an energy minimum in the free energy diagram. It persists for a finite time. A transition state is an energy maximum that is transitory, existing for perhaps the time of a bond vibration, ~10-12 s. Case B: k 1 > k 2 A B C k 1 k 2 slower faster In this scheme, the first step is fast and reversible: A B (fast). When B is formed, it returns to A faster than it proceeds to C . The rate determining (slow) step is B C. Free Energy Progress of Reaction A C B TS 1 TS 2 faster slower B. The rate of formation of product C is Rate = k 2 [B] where the concentration of B is determined by the equilibrium A...
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