HIV_Disease_progession - Acute Infection Stage: normal CD4...

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Acute Infection Stage: normal CD4 count (500-1,200 per ml) at onset Primary infection begins immediately after HIV infects CD4 cells, with initial drop in CD4 ends 2-6 weeks later, return of CD4 count, seroconversion Activity of HIV during acute infection Rapid HIV multiplication Highly infectious T helper cells infected, die 1-2 days later Monocytes infected, become macrophages and cross blood/brain barrier carrying HIV into other tissues (reservoirs) HIV strains different – use CCR-5, slower replication and less deadly to CD4 cells Activity of Immune System Both cell-mediated and humoral immunity activated Immune system “gets the upper hand” temporarily restoring immune function Opportunistic Infections Occasionally see oral and esophageal candidiasis and PCP Symptoms 50% of people have some sort of symptom flu-like: low grade fever, headache, fatigue, swollen lymph nodes, sore throat, rash, diarrhea and muscle aches only severe enough to seek medical attention in 20-30% of these people individuals with severe initial symptoms are more likely to have rapid disease progression Treatment Evidence that anti-retroviral therapies are highly effective in slowing progression at this stage Asymptomatic Phase: CD4 count above 500 Longest stage of HIV disease Not a state of latent infection: 95% have progressing immune system damage
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HIV_Disease_progession - Acute Infection Stage: normal CD4...

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