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6 BIO 326R Metabolism 2 - BIO 326R Metabolism 2...

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    BIO 326R Metabolism 2
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    Pyruvate CO 2 Acetyl CoA NAD + NADH + H + Citrate Isocitrate α ketoglutarate Succinyl CoA Succinate Fumarate Malate Oxaloacetate NAD + NADH + H + CO 2 2C 6C Lipids Alanine Carbohydrates 4C CO 2 NAD + NADH + H + GTP GDP + Pi FAD FADH 2 NAD + NADH + H + 5C 4C Succinate Dehydrogenase Pyruvate to Acetyl CoA is not considered part of the TCA cycle
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    TCA (or Krebs) cycle 5 energy producing steps, 12 ATP per cycle 3 NAD → NADH + H + 3 ATP equivalent each (9 total) FAD → FADH2 2 ATP 1 GDP →GTP 1 ATP GTP + ADP ↔GDP + ATP 12 ATP per cycle means 24 ATP from TCA per molecule of glucose
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    Chemiosmosis ATPase/ATP synthetase ADP + Pi ATP H + Extracellular/Outside Cytoplasm/Inside Electron Transport H + H + H +
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    Electron transport chain Accepts electron pairs from NADH and FADH Reminder: Losing a pair of electrons means NADH and FADH are oxidized when they donate them to the electron transport chain Energy from redox reactions used to move protons across a membrane and create a gradient. ATP can then be made by allowing protons to move back across the membrane.
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    Redox potentials -0.4 Substrates (Glyceraldhehyde phosphate) -0.3 NADH, NADH dehydrogenase -0.2 Flavoprotein, Succinate dehydrogenase 0.0 - +0.2 Ubiquinone 0.0 - +0.4 Cytochromes +0.4 NO3, NO2 +0.8 Oxygen
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    Electron transport - 4 complexes I II III IV NADH UQ Cyt c O 2 FAD H + H + 2e - Inside Outside NADH dehydrogenase Succinate dehydrogenase bc 1 complex Cytochrome Oxidase H +
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