Lecture 8 - Ion channels and disease Hyperkalemic periodic...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Ion channels and disease Hyperkalemic periodic paralysis (HYPP)--muscle. Long QT syndrome (LQT)--cardiac. Lambert-Eaton syndrome (LES)--motor neuron. Ion channels and disease Hyperkalemic periodic paralysis (HYPP)--muscle. Hyperkalemia: blood K + levels; following exercise or eating K +-rich food. Periodic paralysis: a paralysis that occurs periodically. Symptoms: muscle stiffness (myotonia), to paralysis of shoulder, hips, or limbs. Episodes last a few hours. Affects humans and horses (descendents of Impressive). HYPP segregates as a dominant trait. QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture. http://www.tufts.edu/vet/vet_common/images/sports/hypp/figure1.jpg The muscle Na + channels of HYPP patients do not fully inactivate. Normal muscle; HYPP muscle in normal K + HYPP muscle in K + Cannon & Corey, 1993 The muscle action potential is longer The response to increasingly longer duration current pulses Normal HYPP Depolarization of HYPP muscle causes plateau potentials and spontaneous action potentials. Current pulse mimics depolarization due to synaptic activation. Depolarization of HYPP muscle causes plateau potentials and spontaneous action potentials....
View Full Document

This note was uploaded on 07/31/2009 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas at Austin.

Page1 / 24

Lecture 8 - Ion channels and disease Hyperkalemic periodic...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online