Spring 09 lecture 13

Spring 09 lecture 13 - Nature Reviews Cancer 3; Theodor...

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Theodor Hanekamp © 11 Nature Reviews Cancer 3 ; 155-168 (2003); doi:10.1038/nrc1011 ATM AND RELATED PROTEIN KINASES: SAFEGUARDING GENOME
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Theodor Hanekamp © 22
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Theodor Hanekamp © 33 DNA Rearrangement by Genetic Recombination
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Theodor Hanekamp © 44 Genetic Recombination Recombination: Exchange of genetic material between two DNA molecules; causes DNA rearrangement Roles/uses - depends on who/what is causing it; biological and experimental
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Theodor Hanekamp © 55 Biological Roles of (Genetic) Recombination 1. DNA repair 2. Creation of new gene/allele combinations (through crossing over during meiosis) 3. Formation of new genes (e.g., Immuno- globulin rearrangement) 4. Integration of a specific DNA element Experimental Uses of Recombination 1. Gene mapping (distance between genes estimated through recombination frequency) 2. Making transgenic cells and organisms
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Theodor Hanekamp © 66 Genetic recombination (cont.) 1. General or homologous recombination Genetic exchange between a pair of homologous DNA sequences 1. Site-specific recombination : occurs between sequences with a limited stretch of similarity ; involves specific sites (recombination sites) 3. Transposition : mobile DNA element moves from one site to another (donor and target site), usually little sequence similarity involved Three types:
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Theodor Hanekamp © 77 1. General or homologous recombination Genetic exchange between a pair of homologous DNA sequences a) Between two copies of the same chromosome/sister chromatides (mostly in DNA repair in both prokaryotes and eukaryotes) b) Between homologous chromosomes ( crossing-over in meiosis ; also in a type of DNA repair )
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Theodor Hanekamp © 88 Model for homologous recombination - ss break Key steps in ss break model:
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This note was uploaded on 08/03/2009 for the course BIOL BIOL308 taught by Professor Miskovic during the Spring '09 term at Waterloo.

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Spring 09 lecture 13 - Nature Reviews Cancer 3; Theodor...

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