sp08 Final Exam

sp08 Final Exam - FINAL EXAM Biochemistry 102/2008 1 I(25...

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1 FINAL EXAM, Biochemistry 102/2008 I. ( 25 points ) Fill in all of the enzyme catalyzed reactions which convert the substrate on the left to the product on the right. Draw the correct structure for each intermediate molecule. Include the names or abbreviations of any other reactants and products (e.g., ATP, ADP, P i , NAD + , NADH, etc.), and any required prosthetic groups (e.g., TPP, FAD, biotin, etc.). Identify the reaction catalyzed by acetyl CoA carboxylase. (A) Acetyl CoA (cytosol) CH 3 CH 2 CH 2 C(O)–SACP (B) Name the coenzyme from which the prosthetic group of acyl carrier protein is derived. Describe the essential role of this prosthetic group with the aid of a diagram of the fatty acid synthase complex.
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2 II . (35 points ) Fill in all enzyme catalyzed reactions needed to convert the substrate on the left to the product on the right. Draw the correct structure for each intermediate molecule. Include the names or abbreviations of any other reactants and products (e.g., ATP, ADP, P i , NAD + , NADH, etc.), and any required prosthetic groups (e.g., TPP, FAD, biotin, etc.). (A) Pyruvate (gluconeogenesis in liver) ( Indicate which steps occur in the matrix and which occur in the cytosol.) Phosphoenol pyruvate (draw) ----------------------------------------------------------------------------------------------------- - (B) Glucose (glycogen synthesis in the liver) (Show the point on the glycogen polymer to which the entering glucose attaches.) (Glucose) n (Glucose) n+1
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3 (D) Glucose-6-phosphate (draw) Ribose-5-phosphate (draw)
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4 III. (25 points) Draw out all of the enzymatic reactions needed to convert the 15 N labeled amino nitrogens of glutamate and aspartate to urea. Assume that your starting materials are glutamate , aspartate , arginine , and bicarbonate . Include the names or abbreviations of any other reactants and products (eg., ATP, ADP, P i , NAD + , etc.) and any required cofactors (eg., biotin, TPP, etc.) ( Note :you should draw the correct structure for each intermediate molecule, but you don’t need to draw the structure of the enzyme bound intermediates.) (If a structure is incorrectly drawn, you will receive half credit for the correct name of this structure). IV. (20 points) The diagram below is an overview of the major metabolic pathways of fuel metabolism in the liver. You are given that blood [glucose] is low .
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5 A. On this diagram, please enlarge arrows to indicate which pathway steps are activated by low blood [glucose], and put an X through other arrows to indicate which pathway steps are inactivated. (the diagram handed out in lecture will receive full credit). B. On this diagram, please indicate with a number each of the steps at which the phosphorylation of an enzyme target by protein kinase A affects fuel metabolism in the liver when blood [glucose] is low. Identify by name each of the enzyme targets that become phosphorylated by protein kinase A. C.
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This note was uploaded on 08/04/2009 for the course BIBC BIBC 102 taught by Professor Price during the Spring '08 term at UCSD.

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sp08 Final Exam - FINAL EXAM Biochemistry 102/2008 1 I(25...

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