strenuous exercise

strenuous exercise - 4 Lactate dehydrogenase therefore...

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METABOLIC ADJUSTMENT OF MUSCLE TO STRENUOUS EXERCISE 1. Under the aerobic conditions that prevail prior to exercise, NADH is oxidized to NAD+ by oxygen in mitochondria. 2. During strenuous exercise, the supply of oxygen to muscles becomes limiting and NADH builds up. 3. The increase in [NADH] drives the reduction of pyruvate to lactate by lactate dehydrogenase. This regenerates NAD+ and allows step #6 in glycolysis to continue.
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Unformatted text preview: 4. Lactate dehydrogenase therefore provides a temporary storage on lactate of the electron pair generated in step #6. 5. After exercise, the lactate dehydrogenase reaction is reversed, and the excess lactate is converted back to pyruvate plus NADH. The excess NADH produced in this process is then oxidized to NAD+ by oxygen. The excess oxygen consumed in this process is called the oxygen debt....
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