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BIBC 102 handout 3

BIBC 102 handout 3 - BIBC 102 Coleman Section B05 Monday...

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BIBC 102 Coleman JP Abraham Section: B05 Monday 3:00p - 3:50p CENTR 218 [email protected] Handout 3 (10/1 – 10/3) Second order reaction: A + B C ; k has units of 1/sec 2 velocity = ∆C / time = k forward [A][B] K eq = k forward / k reverse at equilibrium = [C] eq / ( [A] eq x [B] eq ) Gibs free energy diagram o standard free energy of molecule o G˚ = H˚ - TS˚ H = enthalpy = energy contained in bonds of reacting molecules S = entropy = degree of randomness in the system Use this to calculate the free energy state of any molecule if you have H and S ∆G˚ = ∆H˚ - T∆S˚ o Use this to calculate the CHANGE in free energy of a reaction o positive ∆G˚ endothermic reaction (endergonic) o negative ∆G˚ exothermic reaction (exergonic) ∆G˚ o standard free energy of activation
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BIBC 102 Coleman JP Abraham Section: B05 Monday 3:00p - 3:50p CENTR 218 [email protected] Handout 3 (10/1 – 10/3) o energy required to reach TS (transition state) o higher standard free activity of activation ~ lower rate constant ~ slower rxn o ∆G˚ = ∆H˚ - T∆S˚ energy is needed to get over ∆H˚ enzyme will help reaction get over ∆S˚ “ ˚ ” stands for under standard conditions standard conditions are: o 298 K, 1M reactants and products, and 1 ATM of pressure this tells us, in general, how thermodynamically favorable a reaction is enzyme catalyzed reactions there is a DIRECT RELATIONSHIP between k / ∆G˚ and catalyst there is NO RELATIONSHIP between K eq / ∆G˚ and catalyst enzymes effect kinetics; k and ∆G˚ relate to one another: reaction rate (k) : increases in both directions standard free energy of activation (∆G˚ ) : decreases in both directions small decrease in ∆G˚ results in large increase in k forward / k reverse enzymes don’t effect thermodynamics; K eq and ∆G˚ relate to one another:
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BIBC 102 Coleman JP Abraham Section: B05 Monday 3:00p - 3:50p CENTR 218 [email protected] Handout 3 (10/1 – 10/3)
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BIBC 102 handout 3 - BIBC 102 Coleman Section B05 Monday...

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