BIBC 102 handout 8 (10_22-10_24)

BIBC 102 handout 8 (10_22-10_24) - BIBC 102 Coleman...

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BIBC 102 Coleman JP Abraham Section: B05 Monday 3:00p - 3:50p CENTR 218 jmabraha@ucsd.edu Handout 8 (10/22 – 10/22) OH at ROMA after section phosphocreatine again, here we see a molecule with a HIGH ENERGY bond (as seen in ATP) o ∆G°´ = -43 kJ/mol during heavy exercise, when [ATP] is low and is NEEDED, creatine’s phosphate group (notation: Pi) can be transferred to ADP to make ATP -43 kJ/mol is used to make ADP to ATP, which is an endergonic reaction phosphorylation of ADP by creatine kinase o INDIVIDUAL REACTIONS 1. P-creatine + H2O creatine + Pi -43kJ/mol 2. ADP + Pi ATP + H2O +30.5 kJ/mol o COUPLED REACTION P-creatine + ADP ATP + creatine -12.5 kJ/mol glutamic acid can be made into glutamine via glutamine synthase note: the only difference between glutamic acid and glutamine is that glutamine is an amide reaction: o glutamic acid + ATP high energy intermediate (glutamic acid connected to phosphate group from ATP) + ADP o intermediate + NH3 glutamine + Pi reaction mechanism:
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o NH3 attacks the R group of the intermediate, kicking off the phosphate group which is connected to the R group what is really happening: o what is really happening is the phosphate group (from ATP) attached to the high energy intermediate forms a HIGH ENERGY BOND, which when broken releases energy , which powers the endergonic addition of NH3 to
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BIBC 102 handout 8 (10_22-10_24) - BIBC 102 Coleman...

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