Week 1 - Lecture Notes

Week 1 - Lecture Notes - Education is not the filling of a...

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Unformatted text preview: Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Welcome! Cal Poly ENGR - 213 Spring, 2006 Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 ENGR 213 Bioengineering Fundamentals Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Cal Poly Dan Walsh Chair BME & GENE Professor of Materials Engineering Bldg 13 Room 260 E-mail: dwalsh@calpoly.edu Phone: X66400 Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 1 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats ENGINEERING 213 Class Policy Cal Poly Each class is two hours long Typical Class Agenda First 15 Minutes - Announcements and Quiz Next 25 Minutes Introduction and Review Next 10 Minutes Discussion of Additional Material / Cases 5 Minute Break @ Midway! Next 50 Minutes Discussion of Additional Material and Cases (Continued) Final 5 Minutes Wrap-up Course lecture slides and readings will be posted on the Cal Poly Blackboard website Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats ENGINEERING 213 Class Policy Cal Poly ENGR 213 Grade will be based on homework, special assignments, quizzes & final Homework and Special Assignments 50% Quizzes 40% Final 10% Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 2 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Outline Cal Poly Engineering in the 21st Century! Growth with Flexibility A brief history of biomedical engineering Bioengineering at the molecular scale Bioengineering at the cellular level Bioengineering at the tissue level Selecting materials for bioengineering applications Bioengineering at the organ level Biomechanics engineering for systems D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Outline Cal Poly Biomedical imaging: boldly going where no man has gone before Product development Engineering to restore form and function Ethics - Do no harm... Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 3 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Learning Objectives Cal Poly Explain how engineering can be applied at the various "scales" of biological systems Explain why bioengineering is inherently multidisciplinary Give examples of how engineers have advanced the field of medicine Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Bioengineering Fundamentals Class 1 Importance and Spectrum of Bioengineering Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 4 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Difference Between Science & Engineering Public Uses Word Science When Engineer is Appropriate Space Program Nuclear Energy Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Scientists study the world as it is... Cal Poly Engineers create the world that never has been -Theodore von Karman Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 5 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Difference Between Science & Engineering Science - Declarative Single Fact Cal Poly Engineering - Subjunctive - Complexity & Ambiguity Many Options Soft Facts Define Best Scientists will admit they are not engineers. Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Difference Between Science & Engineering Scientist Discovers Truth Quantify Knowledge Method as Crucial as Result Cal Poly Engineer Determines Course of Action Proceed With Incomplete or Contradictory Data Question all Results Assume Responsibility Result Crucial / Evaluable Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 6 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Basic Philosophies Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats What a bioengineer is Cal Poly A bioengineer is an individual who is able to apply engineering skills to a biological context Bioengineers can be designers of medical devices and instrumentation Bioengineers can program medical device microcircuitry Bioengineers can design microelectronics, microfluidic devices, micromicroelectromechanical systems Bioengineers can develop materials for biomedical applications Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 7 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Who are bioengineers? Cal Poly Mechanical engineers Electrical and computer engineers Materials Engineers Computer scientists Chemical engineers Environmental engineers Aerospace engineers Who have particular focus on the integration of engineering skills to the biological system Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Where do Bioengineers Work? Medical Device Companies Hospitals Research Centers Federal Government Agencies NHTSA, DOD, Military Cal Poly Aerospace and Transportation Industry Universities Law firms Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 8 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats A 21st Century World Cognitive Revolution Diverse Workforce Information Explosion Global Economy Cal Poly Life-Long Learning International Competition Complex Technologies Finite Resources Environmental Sustainability Distributed Intelligence Defense Reinvestment Shared Wealth Dual Use Demographic Shifts D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Engineering in the 21st Century! Growth with Flexibility Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Technological Impact Practice of Medicine Delivery of Health Care Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 9 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Good Old Days Cal Poly Diseases as "visitations" Supernatural evolve to Empirical Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Superstars! Imhotep 3000BC First Pyramid Architect "bringer of peace" peace" Cal Poly Hippocrates Cataloger of remedies Priest and Scientist scientific spirit Galen Greek, but made roman citizen Romans made contributions to public health, not medicine Galen cataloged observations and treatments Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 10 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats The Eye of Horus Cal Poly Rx Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats More Human Lives Saved By CE Than by MD! Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 11 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Dark Ages Church was Repository Health seen as "Will of God" Stagnant Until Renaissance Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Renaissance Anatomy and Art Medical Schools Henry VIII Secularization Hospitals Lethal Places Florence Nightingale Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 12 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats 1870's Hospital Population Poor Wealthy treated at home Cal Poly No Admittance for Contagious 1 in 20 Surgical (trauma) No "Incurables" Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Modern Medicine Before 1900 Little Demand for MD's MD' Midwives, family nursing, amateur care Cal Poly 1900's Rapid Growth in Sciences 1900' Cross fertilization, chain reaction Technological Innovation X-rays catalysed transition from repository to curative center Sulfa drugs (1933) and Penicillin (1942) Refrigeration (blood banks) Prestige! Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 13 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Modern Medicine Respirator (1939) Angiography (1941) Electron Microscopy Nuclear Tracers Electronics Computerized Tomography Magnetic Resonance Imaging "Spare Parts" Surgery Engineering in the 21st Century! Growth with Flexibility Cal Poly D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats New Trends Finer Scales Cell and Molecular Cal Poly Automation Closed Circuit / Robotic Actuators Far-Reaching Records System Preventative (Preemptive) Medicine Multiphasic Screening Tissue Engineering Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 14 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Daffynitions Bioengineering Cal Poly Improved plants and animals, diagnostic tests, synthetic vaccine, bioenvironmental work, protein-surface interaction, etc... proteinetc... Biomedical Engineering 50's and 60's devices 50' 60' Systems analysis, biosensors, signal processing, artificial organs, AI systems, Medical Imaging, Clinical Engineers Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 15 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Expansion of Clinical Engineering Safety Problems Tip of Iceberg Equipment Non-conformance Non- Cal Poly New Activity Cost-effective use of equipment, purchase of new Costtechnology, standards organizations, formal training of med personnel Events VA BME Districts Clinical Engr Dept at all Hospitals Certification / Professional Societies Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Biomedical Engineer Roles Clinical / Health Care Engineer Cal Poly Problem Solver, Service Relation BME Design Engineer Techno-entrepenuer, Linking Research Scientist Engineer-scientist, model builder Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 16 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Recent Developments in Biomedical Imaging Cal Poly The Given Diagnostic System is based on the patented M2A Ingestible Imaging Capsule, which records color video images as it glides smoothly through the digestive tract and is naturally excreted Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Design of Prosthetics Cal Poly Body-powered Prosthetics "Touch" Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 17 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Cal Poly Artificial Eye Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Professional Education Long exposure Cal Poly Values Standards, Work in Area of Expertise, Objectivity, Clients Interest Before Own Licensed Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 18 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Fundamental Canons Cal Poly 1. Hold paramount the safety, health and welfare of the public. 2. Perform services only in areas of their competence. 3. Issue public statements only in an objective and truthful manner. 4. Act for each employer or client as faithful agents or trustees. 5. Avoid deceptive acts. 6. Conduct themselves honorably, responsibly, ethically, and lawfully so as to enhance the honor, reputation, and usefulness of the profession. Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Biomimicry and the lack of it Cal Poly Biological Surfaces are Curved People Built are Flat We build with right angles rare in living organisms Natural materials are composite, anisotropic and pliant man made stiff and fracture prone Metal huge in our technology not available in nature Nature Uses water as structural material we rarely do (firehoses) (firehoses) Living tissue poor conductors lots of diffusion, Man-made, good conductors, poor Mandiffusers Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 19 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats SCALE Things Are Not Always Linear Whales and Bacteria Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Ranges of Sizes Group Insects Fish Mammals Vascular Plants Algae Range 10-4 to 10-1m 10-2 to 101 m 10-1 to 102 m 10-2 to 102 m Factor 1000 1000 1000 10,000 Cal Poly 10-5 to 100 m 100,000 Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 20 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Length, Surface and Volume Cube Length L Area 6L2 Volume L3 Cal Poly Sphere? S/V proportional to 1/L Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Terminology Genomics Proteomics Systems Biology Organisms Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 21 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 Education is not the filling of a pail, but the lighting of a fire! W.B. Yeats One of many views of Hemoglobin protein structure Cal Poly Engineering in the 21st Century! Growth with Flexibility D. Walsh Cal Poly, SLO, ENGR 213 Sp06 22 ...
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