bams-2014-0012.doc - Matherials and Methods The strength of the relationship between the frequencies of mutations occurred in specific genes(B and

bams-2014-0012.doc - Matherials and Methods The strength of...

This preview shows page 1 - 2 out of 2 pages.

Matherials and MethodsThe strength of the relationship between the frequencies of mutations occurred inspecific genes (B) and exposure to the cancers phenotype (A) was calculated based onthe Z coefficient [1,2]. This coefficient measures the strength of the relationship of twosets of variables (A and B) in a contingency table (). If the events A and B aresubsets of the same space of elementary events, the dependence of the event A event Bcan be describe by:(1) A measure of dependence is the statistics that help assess the strength of relationshipbetween two variables against the background of remaining data (each calculation unitcoefficient takes into account all the values of the entire contingency table). In this casemutated genes and cancer phenotypes association was measured with taking intoaccount mutation occurred in all analyzed genes and cancers. Data was taken from thepublication: “Mutational landscape and significance across 12 major cancer types” [3].Calculation of Z coefficient was carried out in MATLAB [4]. Maps of correlation were
Background image
Image of page 2

You've reached the end of your free preview.

Want to read both pages?

  • Spring '18
  • Dr. Moez
  • Mutation

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes