lecture 9

lecture 9 - Lecture 9: Phenotypes & Gene Interactions II

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BIOL 202 - T. Western 20051 Lecture 9: Phenotypes & Gene Interactions II Complementation testing (test for allelism). Types of interactions among loci. Penetrance and Expressivity. Wrap-up of classical Mendelian and transmission genetics. Reading (9th edition) 235- 249. (8th edition) pp. 197-208.
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BIOL 202 - T. Western 20052 Clicker Question
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BIOL 202 - T. Western 20053 Clicker Question
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BIOL 202 - T. Western 20054 Pathways. ....Pathways. ..... Pathways Biosynthetic. ....... Signal Transduction. ........ Developmental. ....... Gene Interactions
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BIOL 202 - T. Western 20055 Sickled and normal red blood cells Figure 6-5 How we characterize the phenotype may influence the type of dominance we see:
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BIOL 202 - T. Western 20056 Heterozygotes can have the protein of both alleles Figure 6-6 How we characterize the phenotype may influence the type of dominance we see:
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BIOL 202 - T. Western 20057 Studying gene Interactions 1. We often are faced with a series of mutations that influence the same phenotype (e.g., flower colour, coat colour), natural or articficially- induced. 2. These mutations could be alleles of the same or different loci, usually we do not know in advance. 3. Part of the process of studying gene interactions involves first determining whether our mutations are alleles of the same or several different loci. For recessive mutations, we can use the complementation test to find the answer.
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BIOL 202 - T. Western 20058 Harebell plant Interactions between genes in pathways Several varieties of true-breeding white flowered mutants can be found. ...are these mutations of the same or different alleles?
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BIOL 202 - T. Western 20059 Figure 6-15 step 1 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200510 Figure 6-15 step 2 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200511 Figure 6-15 step 3 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200512 Figure 6-15 step 4 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200513 Figure 6-15 step 5 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200514 Figure 6-15 step 6 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200515 Figure 6-15 step 7 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200516 Figure 6-15 step 8 The molecular basis of genetic complementation Complementation testing
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BIOL 202 - T. Western 200517 The molecular basis of genetic complementation Figure 6-15 part 1 Complementation testing
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BIOL 202 - T. Western 200518 The molecular basis of genetic complementation Figure 6-15 part 2 Complementation testing
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BIOL 202 - T. Western 200519 The molecular basis of genetic complementation Complementation testing
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lecture 9 - Lecture 9: Phenotypes & Gene Interactions II

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