lecture 14

lecture 14 - Lecture 14 Genomics: Understanding genomes...

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Lecture 14 Genomics: Understanding genomes Griffiths et al.; Parts of Chapters 1, 13, and 20. (and 2, 5, 8, 9, 19) Published papers and books.
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An overview of genomic analysis (Fig 12.1, 8 th edition)
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Genomics : The genetics subdiscipline of : mapping (we have seen that!) , sequencing and analyzing the function (that is a bit more complicated!) of entire genomes. But why do we need a discipline for this ?
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The complexity of different species … Type Species Complexity Genome size Bacterium E. coli One-cell (prok.) 4 Mb Yeast S. Cerev. One-cell (euk) 15 Mb Nematode C. Elegans 959 cells (Female) 100 Mb 1031 cells (Male) Fly D. Melano. 50,000 cells 180 Mb Mouse M. Musculus 10 11 cells 3,000 Mb Human Homo sapiens 10 14 cells 3,000 Mb ( C -value paradox)
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Necessitates important tools: The cardinal points of genetics Fig 1-12
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Detecting gene expression: Northern blot Hartwell Figure 10.16 The principle. .. DNA RNA Proteins
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… and the results Detecting gene expression: Northern blot Hartwell Figure 10.16 specificity and loading control
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Fig. 1-12
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DNA RNA Proteins Detecting protein expression: Western blot Total protein G l u t a m i n e s y h An antibody recognize a specific protein
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from your library does not contain YMWG? You are here!
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lecture 14 - Lecture 14 Genomics: Understanding genomes...

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