Final_2001_key - Bio 115 Winter 2001 Final Exam Name...

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Bio 115 Winter 2001 Name:_________________________ Final Exam ____________________________________________________________________________________________________ - 1 - Total:____________ Instructions: Write your name in ink at the top of every page. Do not write on the back of pages. Restrict your answers to the space provided. Q. What did one math text book say to the other math textbook? A. I’ve got more problems than you. ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ Answer the following questions with "true" or "false". Provide your reasoning for each "false" answer. Correct "true" answers are worth 1 point. Correct "false" answers with appropriate reasoning are worth 3 points. 1. The catalytic residue of the ribosomal peptidyl transferase is provided by a lysine of a ribosomal protein. False- The peptidyl transferase reaction is catalyzed by rRNA. 2. eIF4A hydrolyzes ATP and removes secondary structure from mRNAs. True 3. One way that eukaryotes regulate translation initiation is by phosphorylating eIF2a, which prevents it from being recycled into new, functional, ternary complexes. True 4. mRNA is typically degraded by first decapping the message, then rapidly degrading the poly-A tail, followed by degradation of the rest of the message. False- First, the polyA tail is slowly shortened. When the tail is so short that no PAB protein can bind it, the 5’ cap is removed and the message is rapidly degraded in a 5’ to 3’ direction. 5. One common feature of both eukaryotic and prokaryotic DNA replication is that origin recognition is an ATP dependent process. True
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Name:_________________________ Final Exam ____________________________________________________________________________________________________ - 2 - Total:____________ 6. At a replication fork, leading strand and lagging strand synthesis do not need to be coordinated with each other, since two separate strands of DNA are being synthesized. False- They are coordinated by a protein subunit that holds them together (tau in E. coli). 7. Transcription coupled DNA repair is a specialized form of double strand break repair. False- It is a form of nucleotide excision repair (NER). 8. The RNA component of telomerase provides the catalytic activity for addition of telomeric repeats. False- The catalytic activity is provided by the reverse transcriptase (RT), which is a protein. ( or, The RNA component of telomerase provides the template for synthesizing the repeats.) 9. Once a Holliday junction has formed, branch migration must occur if a region of heteroduplex DNA is to be formed. True 10. Transposons can act as mutagens. True 11. Eukaryotes can repair UV induced DNA damage via direct reversal, using photolyase and white light. True
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Final_2001_key - Bio 115 Winter 2001 Final Exam Name...

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