sample3Final

sample3Final - Bio 115, Final Exam Name_ Instructions:...

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Bio 115, Final Exam Name________________________________ ________________________________________________________________________ page 1 page total: Instructions: Write your name in ink at the top of every page. Do not write on the back of pages. Restrict your answers to the space provided. +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 1. a. Diagram the central dogma of molecular biology. (2 pts.) b. Label the two straight arrows. (2 pts.) c. Give two examples of exceptions to the central dogma. (2 pts.) +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 2. a. Diagram a typical eukaryotic Pol II gene (DNA) sitting in the genome: Designate the following features: transcription initiation site, core promoter, terminator, enhancer elements, polyadenylation site, three exons, two introns, upstream regulatory element, transcription unit, untranslated regions, (4 pts.) b. Diagram the unprocessed pre-mRNA transcript that would correspond to this gene. (2 pts.) c. The second exon can be skipped by alternative splicing. Diagram the possible mRNA products of this gene after RNA processing. (3 pts.)
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Bio 115, Final Exam Name________________________________ ________________________________________________________________________ page 2 page total: Answer the following questions with "true" or "false". (3 points each) For each "true" answer, give an example or explanation to support the statement. For each "false" answer, explain why the statement is false. 3. Guanosine serves as the nucleophile in the first step of pre-mRNA splicing. 4. Transcription factors recognize specific DNA sequences by making hydrogen bonds with the phosphate backbone. 5. Microarray analysis can only indirectly compare protein expression profiles between two experimental conditions. 6. Shotgun sequencing strategies rely on sequencing a given chromosomal region more than one time. 7. A single “jumping” event of a transposon can affect more than one gene. 8. Retroviruses use reverse transcriptase to express their genomes. 9. A larger numbers of genes is the primary explanation for the greater complexity of multicellular eukaryotes when compared to simpler prokaryotes. 10. The polyadenylation site for a RNA Pol II transcript is specified by a protein-DNA interaction.
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Bio 115, Final Exam Name________________________________ ________________________________________________________________________ page 3 page total: 11. Peptide bond formation is thought to be catalyzed by a ribozyme. 12.
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sample3Final - Bio 115, Final Exam Name_ Instructions:...

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