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Cancer biol lecture - Tumor formation requires a large...

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Tumor formation requires a large number of cell divisions Cancer cells have unlimited proliferative potential: i.e they are immortal
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Limits to proliferation Precancerous lesions are quite common Cells have gained the capacity to overcome growth barriers but lesions never develop into tumors. Why? The cell environment limits cell division (i) Apoptosis (ii) Senescence after a limited number of population doublings Overcome via changes in signaling pathways (cell cycle, growth factor etc) Precancerous lesions
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