Invasion 2007a - Tumor Cell Invasion Robert Hennigan, Ph.D....

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Tumor Cell Invasion Robert Hennigan, Ph.D. Department of Cancer and Cell Biology Vontz Center for Molecular Medicine Rm. 3302, (513) 558-2253
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The largest tumor ever removed intact was a multicystic mass of the right ovary weighing 303 pounds. The growth had a diameter of 3 feet.
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Metastasis Breast Adenocarcinoma The systemic dissemination and subsequent growth of tumor cells at a distant site.
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Metastasis Malignant Melanoma Metastasis has occurred at the time of time of diagnosis in ~50% of patients.
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Metastasis Breast Cancer Metastasis is a direct cause of mortality in cancer patients.
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Defining Characteristics of Neoplastic Cells Deregulated Proliferation Genetic Instability Suppression of Apoptosis Evasion of Host Immune Response Angiogenesis Malignant Invasion of Surrounding Tissues Metastatic Spread and Growth at Distant Sites
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Malignant Invasion of Surrounding Tissues Normal Skin Squamous Carcinoma in situ nvasive Squamous Cell Carcinoma Basement Membran Stratum Corneum Epidermis Dermis
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Breach the basement membrane. (Local Invasion) Gain access to the vasculature or lymphatics. (Intravasation) Systemic dissemination. Escape form the vasculature or lymphatics. (Extravasation Establishment at distant sites. (Micrometastases) Growth at distant sites. (Macrometastases) Metastasis is a Multi-step process
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Tumor Cell Invasion is Critical for Metastasis Detachment: Loss of cell-cell and cell- substrate adhesion. Motility: Increased autonomous migration. Degradation: Expression of proteolytic
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Cell Motility and Invasion in Normal Processes Immune Response Neutrophils Macrophages Dendritic cells Wound Healing. Myofibroblast differentiation. Re-epiltheliation. Development. Epithelial to Mesenchymal Transition.
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Epithelial to Mesenchymal Transition The conversion of epithelial cells into mesenchymal cells during development. Loss of epithelial phenotype. Cell to cell adhesion, apical-basolateral polarization, epithelial gene expression. Not Invasive. Gain of a mesenchymal phenotype. Loss of cell to cell adhesion, enhanced motility, mesenchymal gene expression. Invasive.
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EpH4 Green: E-cadherin Red: Vimentin Rat NBT-II Carcinoma Red: Desmoplakin Green: Vimentin Pre-EMT Post-EMT SCp2 Red: Actin Blue: DNA Suppression of epithelial genes such as E- cadherin. Expression of
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This note was uploaded on 08/17/2009 for the course 26CB 880 taught by Professor Khan during the Spring '07 term at University of Cincinnati.

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Invasion 2007a - Tumor Cell Invasion Robert Hennigan, Ph.D....

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