RV and cancer 2008 - Retroviruses & cancer Biology of...

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Biology of Cancer 2008 David Askew, Dept. of Pathology
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Widespread in nature Disease association Neurodegeneration Immunodeficiency Cancer
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History 1911 Peyton Rous – Rous sarrcoma virus 1930 Bittner: milk-transmitted mammary tumor virus 1960 Nobel prize: Peyton Rous 1960’s Temin proposes reverse transcription 1975 Nobel prize: Temin & Baltimore 1981 – HTLV 1983 – HIV 1989 Nobel prize: Bishop & Varmus
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Classification Enveloped, RNA viruses Diploid (+) strand RNA (SS) Replicate by a DNA intermediate Subfamilies: Oncoviruses Lentiviruses Spumaviruses Host range Ecotropic, Amphotropic, Xenotropic
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Goff Nature Reviews Microbiology advance online publication; published online 26 February 2007 | doi:10.1038/nrmicro1541 Lifecycle
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Retroviruses in cancer biology Tools for understanding carcinogenesis Simple retroviruses Complex retroviruses HTLV and HIV Tools for gene delivery
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Simple Retroviruses R U5 Ψ U3 R Gag Pol Env AAAA Reverse transcription U3 R U5 Gag Pol Env U3 R U5 Provirus
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Simple oncogenic retroviruses Acutely transforming Induce tumors within weeks Rapidly transform cells in culture Nonacutely transforming Induce tumors within months to years Do not transform cells in culture
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Acutely transforming retroviruses Identification of v-onc RSV, a filterable sarcomagenic agent Mutants Transformation-defective mutants (TF not required for replication) Ts and deletion mutants identified a 3’ gene gag pol env src 5’ 3’
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v-onc ? 1976: src cDNA hybridizes to
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RV and cancer 2008 - Retroviruses & cancer Biology of...

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