L40S07_ChemvsBiochem 04-27-07

L40S07_ChemvsBiochem 04-27-07 - CHEM 1A, L- 40:...

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Unformatted text preview: CHEM 1A, L- 40: "Chemistry vs. Biochemistry" Standard Reduction Potentials MnO4- + 8 H3O+ + 5 eAu+3 + 3 eO2 (g) + 4 H3O+ + 4 eBr2 (l) + 2 eNO3- (g) + 4 H3O+ + 3 eAg+1 + 1 eO2 (g) + 2 H2O + 4 eCu+2 + 2 e2 H3O+ + 2 eNi+2 + 2 eFe+2 + 2 eZn+2 + 2 e2 H2O + 2 eMg+2 + 2 eNa+ + 1 eCa+2 + 2 e- (V) +1.49 +1.42 +1.23 +1.06 +0.80 +0.40 +0.34 0.00 -0.23 -0.41 -0.76 -0.83 -2.36 -2.71 -2.76 Balancing Redox Equations MnO4- + 8 H3O+ + 5 eBr2 (l) + 2 e2 MnO4- + 16 H3O+ + 10 Br- Summary Au 6 H2O 2 BrAg 4 OHCu Mn2+ + 12 H2O - Mn2+ + 12 H2O x 2 10 e2 Brx 5 10 e5 Br2 (l) + 2 Mn2+ + 24 H2O Free energy and cell potential G = - nF eReducer Oxidizer A.Pines,M.Kubinec,UCB NO (g) + 6 H2O +0.96 G L40-2 H2 + 2 H2O (l) Ni Fe Zn H2 + 2 OHMg Na Ca Examples Rusting of Iron - Fe Fe+2 OH- O2 Pt + = +0.81 V O2 + 2 Fe + 2 H2O 2 Fe+2 + 4 OHAutoioniztion of water - Pt H2 OH- H3O+ H2 Pt + = +0.83 V H3O+ + OHA.Pines,M.Kubinec,UCB 2 H2O L40-1 L40-3 2004 M. Kubinec, A. Pines ChemQuiz 39.04 Which of the following will plate out on Cu from solution? 1.0 M A) Ca 2004 M. Kubinec, A. Pines B) Ag C) Au L40-2 Summary ATP and Metabolism C6H12O6 (1 mole) ATP 38 moles ATP Proteins ~4 moles Peptide Bonds CO2 + H2O 2004 M. Kubinec, A. Pines 2000 University of California ADP Free Amino Acids L40-4 L28-17 2004 M. Kubinec, A. Pines 1 CHEM 1A, L- 40: "Chemistry vs. Biochemistry" ATP as an Acid Adenine s te ha sp o Ph P P P Ribose Adenosine Triphosphate: ATP Triphosphate: L40-5 2004 M. Kubinec, A. Pines ATP as an Acid ~6 pK a H H H pKa ~ 2 H 2004 M. Kubinec, A. Pines L40-6 ATP as an Acid - - - pH = 7.0 2004 M. Kubinec, A. Pines L40-7 2004 M. Kubinec, A. Pines 2 CHEM 1A, L- 40: "Chemistry vs. Biochemistry" ATP "High Energy" Bond + H2O G = -30 kJ/mol H = -20 kJ/mol S = +34 J/molK J/molK 2004 M. Kubinec, A. Pines ADP + HPO4 + H+ -2 L40-8 ATP Hydrolysis ADP + HPO4 + H+ -2 2004 M. Kubinec, A. Pines L40-9 ChemQuiz 40.1 Certain bacteria live around oceanic thermal vents at 100+ C. Can the hydrolysis of ATP provide energy for these organisms? 1) Yes 2004 M. Kubinec, A. Pines 2) No 3) Can't tell Can' L40-10 2004 M. Kubinec, A. Pines 3 CHEM 1A, L- 40: "Chemistry vs. Biochemistry" Catabolic Redox C6H12O6 + 6 O2 H C OH 0 H C OH H H H H C C C C OH OH OH OH 0 6 CO2 + 6 H2O +4 O=O C, oxidized O=C=O O, reduced H O -2 H 2004 M. Kubinec, A. Pines L40-12 Catabolic Redox xs H+ eH+ e+ + 2H+ O2 (pH) gradient xs H+ H2O H+ ADP C6H12O6 CO2 ATP L40-13 2004 M. Kubinec, A. Pines Mitochondria ChemQuiz 40.2 How does the pH inside mitochondria compare to cytoplasm during ATP synthesis? synthesis? image courtesy of: www.hybridmedicalanimation.com 1) pHm > pHc 2) pHm = pHc 3) pHm < pHc 2004 M. Kubinec, A. Pines L40-14 2004 M. Kubinec, A. Pines 4 CHEM 1A, L- 40: "Chemistry vs. Biochemistry" C6H12O6 (1 mole) ATP and Metabolism ATP 38 moles ATP Proteins catabolism anabolism ~ 3000 kJ ~4 moles Peptide Bonds CO2 + H2O 2004 M. Kubinec, A. Pines ADP Free Amino Acids L40-16 ChemQuiz 40.3 Combustion of glucose releases about 3000 kJ/mol. How efficiently is this stored as ATP ? C6H12O6 (1 mole) ATP 38 moles ATP ADP ~ 3000 kJ CO2 + H2O 1) ~90% 2004 M. Kubinec, A. Pines 2) ~60% 3) ~40% L40-17 ChemQuiz 40.4 How many grams of glucose are required to make 1 mole of Serum Albumin (~100 A1) ? 1) 50 2) 500 3) 5000 2004 M. Kubinec, A. Pines L40-19 2004 M. Kubinec, A. Pines 5 CHEM 1A, L- 40: "Chemistry vs. Biochemistry" Proton Transfer Ammonia to water Proton transfer in enzymes Bio-motors and proton transfer Coupling to glycolysis 2004 M. Kubinec, A. Pines L40-21 Lecture Complete 2004 M. Kubinec, A. Pines L40-22 2004 M. Kubinec, A. Pines 6 ...
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This note was uploaded on 08/19/2009 for the course CHEM 1A taught by Professor Nitsche during the Spring '08 term at Berkeley.

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