L37S07_Polyprotic Acids, Amino Acids 04-20-07

Pka2 pka1 1 h2co3 apinesmkubinecucb 2 hco3 1 3

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Unformatted text preview: A.Pines,M.Kubinec,UCB 2) HCO3 -1 3) CO3 -2 L37-9 PolyProtic Acids/Blood Buffer Blood pH Stats: pH PCO = 40 torr 2 pKa2 pKa1 +OHA.Pines,M.Kubinec,UCB [CO2] = 1.2 mM [CO2] = [H2CO3] Carbonic Anhydrase Kidneys Lungs Henry's Law Henry' [HCO3-] = 24 mM L37-11 PolyProtic Acids/Blood Buffer Blood pH Stats: Henry's Law Henry' 24] [[24] 3-] HCO pH = pKa + log 6.1 [H2CO3] [CO2] = 1.2 mM [1.2] 1.2] [CO2] = [H2CO3] [H Carbonic Anhydrase pH = 7.4 [HCO3-] = 24 mM Kidneys PCO = 40 torr 2 Lungs A.Pines,M.Kubinec,UCB L37-12 A.Pines,M.Kubinec,UCB 3 Chem 1A L 37: "Polyprotic Acids, Amino Acids " 9.0 Amino Acid pKa's C C C C +N -O O C C + N 9.1 pH = 7.0 10.5 10.1 C C C C C C O 2.2 Lysine O +N 2.2 C C C - O Tyrosine A.Pines,M.Kubinec,UCB L37-13 Amino Acid pKa's +N 2.0 O 10 O C C C 3.9 O 9.2 N N C C C C pH = 7.0 C O - Aspartic Acid O O + C N N C C C N N 6.0 C C A.Pines,M.Kubinec,UCB 1.8 O O Histidine L37-14 ChemQuiz 37.2 Solution pKa: pKa= 9.0 pH < pKa: acid form pH 5.0 - N + + C O C C S pH < pKa: acid form pKa: pKa= 8.0 pH > pKa: base form pKa: pKa= 2.2 1) + 1 A.Pines,M.Kubinec,UCB 2) 0 3) -1 L37-16 A.Pines,M.Kubinec,UCB 4 Chem 1A L 37: "Polyprotic Acids, Amino Acids " Lecture complete A.Pines,M.Kubinec,UCB L37-17 A.Pines,M.Kubinec,UCB 5...
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This note was uploaded on 08/19/2009 for the course CHEM 1A taught by Professor Nitsche during the Spring '08 term at University of California, Berkeley.

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