Ex3_Fall06 - Molecular Biology 1Bio 344 Exam III Fall 2006...

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Molecular Biology, 1Bio 344, Exam III Fall 2006 (11/27/06) Name ______________________________________ UTEID________________________________ Answer questions 1-43 on the scantron, selecting the best (most complete) answer (each question is worth 2.25 pts). Answer question 44 or 45 on the test itself. Good luck! 1. Which of the following best describes the 5' end of a Capped mRNA? a. GpG b. 7Me GpG c. 7Me GpppG d. G 2. The enzyme that adds the main part of the Cap to the 5' end of nuclear pre-mRNA is a. nucleotide phosphohydrolase b. guanylyl transferase c. methyl transferase d. G-specific terminal transferase 3. Which is/are true concerning the function of poly-A polymerases (PAPs) in mRNA processing? a. They function in the nucleus, and not the cytoplasm b. They do not use a template strand c. They do not use a priming strand d. both a and b are true e. both b and c are true 4. The half-life of alpha globin mRNA in vivo is a. equal to the time it takes for half of the mRNA population to be synthesized b. equal to the time it takes for half the mRNA population to be degraded c. determined from a plot of “% alpha globin mRNA remaining” versus time (and preferably under conditions where transcription has stopped) d. both b and c are correct 5. In the experiment that demonstrated the two phases of polyadenylation, phase II a. occurred on an RNA substrate with a short poly-A tail b. was not blocked by a mutated AAUAAA c. was blocked by a mutated AAUAAA d. both a and b e. both a and c 6. The protein(s) that is/are not specifically required for phase I of polyadenylation a. CPSF b. PAP II (nuclear poly-A polymerase) c. PAB II (nuclear poly-A binding protein) d. CFI and CFII e. both c and d 7. The protein that binds to the G-U/U signal sequence is a. CFI b. CPSF c. CstF d. CFII 8. True or False. Introns were first discovered using R-loop analysis of Tetrahymena RNAs. a. True b. False 9. Introns in organellar (chloroplast & mitochondria) genes include a. Group I b. Group II c. those that can self-splice in vitro d. a and b e. all of the above 1
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10. The first RNA shown to be catalytic in vitro (i.e., a ribozyme) was a. Tetrahymena rRNA group I intron b. a bacterial Group II intron c. bacterial RNase P RNA (M1) d. the 23S rRNA 11. Structural features of RNA learned from studying Group I introns include a. helical regions tend to stack on top of one another b. triple base-paired regions (triple helices) c. long-range base pairing (between sequences that are not close together in the primary sequence)
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This note was uploaded on 08/24/2009 for the course BIO 344 taught by Professor Herrin during the Summer '08 term at University of Texas.

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Ex3_Fall06 - Molecular Biology 1Bio 344 Exam III Fall 2006...

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