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Unformatted text preview: ? 9. How would siRNA against Ced-3 affect the development of C. elegans? 12. What is the critical property of stem
cells? 10. You have isolated a polypeptide from
a toxic plant, which localizes to mitochondria after endocytosis by mammalian
cells. The polypeptide aggregates and 13. What are the potential advantages of
embryonic stem cells as compared to
adult stem cells for therapeutic applications? 3. You have expressed mutants of nuclear
lamins in human fibroblasts. The Asp
residue in the caspase cleavage site has
been mutated to Glu in these lamins.
How would these mutant lamins affect
the progression of apoptosis?
4. How do Bcl-2 family proteins regulate
apoptosis in mammalian cells?
5. How does p53 activation in response
to DNA damage affect cell cycle progression and cell survival?
6. You have constructed a Bad mutant in
which the Akt phosphorylation site has References and Further Reading
Programmed Cell Death
Danial, N. K. and S. J. Korsmeyer. 2004. Cell
death: Critical control points. Cell 116...
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