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Unformatted text preview: as the contractile portions of the
digestive and respiratory tracts and other internal organs, are also capable
of resuming proliferation in response to growth factor stimulation. In contrast, differentiated skeletal and cardiac muscle cells are no longer able to
divide. Tissue deprived of oxygen VEGF
response to VEGF Capillary FIGURE 17.15 Proliferation of endothelial cells
Endothelial cells are stimulated to proliferate by vascular
endothelial growth factor (VEGF). VEGF is secreted by
cells deprived of oxygen, leading to the outgrowth of
new capillaries into tissues lacking an adequate blood
supply. This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher.
© 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS
16 CHAPTER 17 FIGURE 17.16 Liver regeneration Liver cells are normally arrested in G0 but
resume proliferation to replace damaged tissue. If two-thirds of the liver of a rat is
surgically removed, the remaining cells proliferate to regener...
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