Cooper5e_Ch17

15 smooth muscle cells which form the walls of larger

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Unformatted text preview: as the contractile portions of the digestive and respiratory tracts and other internal organs, are also capable of resuming proliferation in response to growth factor stimulation. In contrast, differentiated skeletal and cardiac muscle cells are no longer able to divide. Tissue deprived of oxygen VEGF Endothelial cells proliferate in response to VEGF Capillary FIGURE 17.15 Proliferation of endothelial cells Endothelial cells are stimulated to proliferate by vascular endothelial growth factor (VEGF). VEGF is secreted by cells deprived of oxygen, leading to the outgrowth of new capillaries into tissues lacking an adequate blood supply. This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS 16 CHAPTER 17 FIGURE 17.16 Liver regeneration Liver cells are normally arrested in G0 but resume proliferation to replace damaged tissue. If two-thirds of the liver of a rat is surgically removed, the remaining cells proliferate to regener...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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