2009 sinauer associates inc 25 heart muscle cells

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Unformatted text preview: Transfer adult nucleus to enucleated egg Culture to early embryo Blastocyst Implant in foster mother FIGURE 17.25 Cloning by somatic cell nuclear transfer (A) The nucleus of an adult somatic cell is transferred to an unfertilized egg from which the normal egg chromosomes have been removed (an enucleated egg). The egg is then cultured to an early embryo and transferred to a foster mother, who then gives birth to a clone of the donor of the adult nucleus. (B) Dolly (the adult sheep, left) was the first cloned mammal. She is shown with her lamb, Bonnie, who was produced by normal reproduction. (Photograph by Roddy Field; courtesy of T. Wakayama and R. Yanagimachi.) Somatic Cell Nuclear Transfer Clone T he isolation of human embryonic stem cells in 1998 followed the first demonstration that the nucleus of an adult mammalian cell could give rise to a viable cloned animal. In 1997 Ian Wilmut and his colleagues initiated a new era of regenerative medicine with the cloning of Dolly the sheep (Figure 17.25). Dolly arose from the nucleus of a mam...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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