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Unformatted text preview: lation of a Pluripotent Cell Line from Early Mouse
Embryos Cultured in Medium Conditioned by
Teratocarcinoma Stem Cells
Gail R. Martin
University of California at San Francisco
Proceedings of the National Academy of Science, USA, 1981,
Volume 78, pages 7634–7638 The Context
The cells of early embryos are unique
in their ability to proliferate and differentiate into all of the types of cells that
make up the tissues and organs of
adult animals. In 1970 it was found
that early mouse embryos frequently
developed into tumors if they were
removed from the uterus and transplanted to an abnormal site. These
tumors, called teratocarcinomas, contained cells that were capable of forming an array of different tissues as they
grew within the animal. In addition,
cells from teratocarcinomas (called
embryonal carcinoma cells) could be
isolated and grown in tissue culture.
These cells resembled normal embryo
cells and could be induced to differentiate into a variety of cell types in culture. Some embryonal carc...
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