2009 sinauer associates inc uncorrected page proofs c

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Unformatted text preview: lation of a Pluripotent Cell Line from Early Mouse Embryos Cultured in Medium Conditioned by Teratocarcinoma Stem Cells Gail R. Martin University of California at San Francisco Proceedings of the National Academy of Science, USA, 1981, Volume 78, pages 7634–7638 The Context The cells of early embryos are unique in their ability to proliferate and differentiate into all of the types of cells that make up the tissues and organs of adult animals. In 1970 it was found that early mouse embryos frequently developed into tumors if they were removed from the uterus and transplanted to an abnormal site. These tumors, called teratocarcinomas, contained cells that were capable of forming an array of different tissues as they grew within the animal. In addition, cells from teratocarcinomas (called embryonal carcinoma cells) could be isolated and grown in tissue culture. These cells resembled normal embryo cells and could be induced to differentiate into a variety of cell types in culture. Some embryonal carc...
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