27 subsequent studies have shown that induced

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Unformatted text preview: early mouse embryos. That the action of only four key transcription factors is sufficient to reprogram adult somatic cells to pluripotent stem cells is a remarkable finding, which raises a number of intriguing questions as to the transcriptional programs that control cell fate. Importantly, further research has also demonstrated that adult human fibroblasts can be reprogrammed to pluripotency by a similar procedure. Thus, it is now possible to convert skin cells from a patient directly to induced pluripotent stem cells in culture, providing a new route to the derivation of pluripotent stem This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. 27 Culture embryonic stem cells Differentiate to desired cell type (e.g., neurons) Transplant back to patient UNCORRECTED PAGE PROOFS 28 CHAPTER 17 Adult mouse fibroblast Infection with retroviruses carrying genes for Oct3/4, Sox2, Klf4 and c-...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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