Cooper5e_Ch17

Apoptosis ced 9 ced 4 ced 3 this material cannot be

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Unformatted text preview: osis Ced-9 Ced-4 Ced-3 This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. FIGURE 17.3 Programmed cell death in C. elegans Genetic analysis identified three genes that play key roles in programmed cell death during development of C. elegans. Two genes, ced-3 and ced-4, are required for cell death, whereas ced-9 inhibits cell death. The Ced-9 protein acts upstream of Ced-4, which activates Ced-3. UNCORRECTED PAGE PROOFS 6 CHAPTER 17 FIGURE 17.4 Caspase targets Caspases cleave over 100 cellular proteins to induce the morphological alterations characteristic of apoptosis. Caspase targets include an inhibitor of DNase (ICAD), nuclear lamins, cytoskeletal proteins, and Golgi matrix proteins. Caspases ICAD Inhibitor of DNase Nuclear lamins DNA fragmentation Fragmentation of nucleus Cytoskeletal proteins Actin, myosin, a-actinin, tubulin, vimentin Cell fragmentation, membrane blebbing Golgi matrix proteins Fragmentation of Golgi Ced-3 is the only caspase in C. elegans. However, D...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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