Cooper5e_Ch17

B courtesy of d r greenla jolla institute for allergy

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Unformatted text preview: sis. (B, courtesy of D. R. Green/La Jolla Institute for Allergy and Immunology; C, courtesy of Ken Adams, Boston University.) This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS CELL DEATH AND CELL RENEWAL Normal cell Cytosol Outside of cell – – – Phosphatidylserine FIGURE 17.2 Phagocytosis of apoptotic cells Apoptotic cells and cell fragments are recognized and engulfed by phagocytic cells. One of the signals recognized by phagocytes is phosphatidylserine on the cell surface. In normal cells, phosphatidylserine is restricted to the inner leaflet of the plasma membrane, but it becomes expressed on the cell surface during apoptosis. Apoptosis Receptor – – – Phagocytic cell usually fragmented as a result of cleavage between nucleosomes. The chromatin condenses and the nucleus then breaks up into small pieces. Finally, the cell itself shrinks and breaks up into membrane-enclosed fragments called apoptoti...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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