Cooper5e_Ch17

Caspase 8 is recruited to the receptor and activated

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Unformatted text preview: molecules (the extrinsic pathway of apoptosis). Once activated, caspase-8 can directly cleave and activate effector caspases. In addition, caspase-8 cleaves the BH3-only protein Bid, which activates the intrinsic pathway of apoptosis, leading to caspase-9 activation. TNF TNF receptor Cytosol Adaptor Caspase-8 Bid activation Bid Effector caspase activation Bak/Bax Mitochondrion Caspase-9 activation Effector caspase activation portions of the receptors bind adaptor molecules that in turn bind caspase8. This leads to activation of caspase-8, which can then cleave and activate downstream effector caspases. In some cells, caspase-8 activation and subsequent activation of caspases-3 and -7 is sufficient to induce apoptosis directly. In other cells, however, amplification of the signal is needed. This This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS CELL DEATH AND CELL RENEWAL results...
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