Caspases are also regulated by a family of proteins

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Unformatted text preview: by a family of proteins called the IAP, for inhibitor of apoptosis, family. Members of the IAP family directly interact with caspases and suppress apoptosis by either inhibiting caspase activity or by targeting caspases for ubiquitination and degradation in the proteasome. IAPs are present in both Drosophila and mammals (but not C. elegans), and regulation of their activity or expression provides another mechanism for controlling apoptosis. Regulation of IAPs is particularly important in Drosophila, where initiator caspases are chronically activated but held in check by IAPs ( Figure 17.9 ). Many signals that induce apoptosis in Drosophila function by activating proteins that inhibit the IAPs, thus leading to caspase activation. In mammalian cells, the permeabilization of mitoThis material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS CELL DEATH AND CELL RENEWAL FIGURE 17.8 The mitochondrial pathway...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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