Caspases are classified as either initiator or

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Unformatted text preview: complex called the apoptosome, which also requires cytochrome c released from mitochondria. Bcl-2, IAP Central Regulators of Apoptosis: the Bcl-2 Family: Members of the Bcl2 family are central regulators of caspase activation and apoptosis. Some members of the Bcl-2 family function to inhibit apoptosis (antiapoptotic) whereas others act to promote apoptosis (proapoptotic). Signals that control programmed cell death alter the balance between proapoptotic and antiapoptotic Bcl-2 family members, which regulate one another. In mammalian cells, proapoptotic Bcl-2 family members act at mitochondria, where they promote the release of cytochrome c, leading to caspase activation. Caspases are also regulated directly by inhibitory IAP proteins. This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS C ELL DEATH AND CELL RENEWAL SUMMARY 29 KEY TERMS Signaling Pathways that Regulate Apoptosis: A variety of signaling pathways regula...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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