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Unformatted text preview: ion from the publisher. © 2009 Sinauer Associates, Inc. UNCORRECTED PAGE PROOFS 24 CHAPTER 17 KEY EXPERIMENT Culture of Embryonic Stem Cells (continued ) experiment was repeated with additional mouse embryos. The cell lines derived from normal embryos (embryonic stem cells) closely resembled the embryonal carcinoma cells derived from tumors. Most importantly, the embryonic stem cells could be induced to differentiate in culture into a variety of cell types, including endodermal cells, cartilage, and neuron-like cells (see figure). Moreover, if the embryonic stem cells were injected into a mouse, they formed tumors containing multiple differentiated cell types. It thus appeared that embryonic stem cell lines, which retained the ability to differentiate into a wide array of cell types, could be established in culture from normal mouse embryos. The Impact The establishment of embryonic stem cell lines has had a major impact on studies of mouse genetics and development as well as opening new...
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