Cooper5e_Ch17

Continuing studies identified an additional mutation

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Unformatted text preview: lopment. Continuing studies identified an additional mutation that was similar to ced-3 in preventing programmed cell H. Robert Horvitz death. However, this mutation was in a different gene, which was located on a different chromosome than ced-3. This second gene was called ced-4. Similar to mutations in ced-3, recessive mutations in ced-4 were found to block all programmed cell deaths in the worm. The Impact The isolation of C. elegans mutants by Ellis and Horvitz provided the first identification of genes that were involved in the process of programmed cell death. The proteins encoded by the ced-3 and ced-4 genes, as well as by (A) (B) Photomicrographs of a normal worm (A) and a ced-3 mutant (B). Dying cells are highly refractile and are indicated by arrows in panel A. These cells are not present in the mutant animal. This material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, I...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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