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Unformatted text preview: ting apoptosis. During normal nematode development, 131
somatic cells out of a total of 1090 are eliminated by programmed cell death,
yielding the 959 somatic cells in the adult worm. The death of these cells is
highly specific, such that the same cells always die in developing embryos.
Based on this developmental specificity, Robert Horvitz undertook a
genetic analysis of cell death in C. elegans with the goal of identifying the
genes responsible for these developmental cell deaths. In 1986 mutagenesis
of C. elegans identified two genes, ced-3 and ced-4, that were required for
developmental cell death. If either ced-3 or ced-4 was inactivated by mutaThis material cannot be copied, reproduced, manufactured, or disseminated in any
form without express written permission from the publisher.
© 2009 Sinauer Associates, Inc. 3 The term apoptosis is derived
from the Greek word describing
the falling of leaves from a tree or
petals from a flower. It was coined
to differentiate this form of programmed cell death from the accidental cell deaths caused by inflamma...
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