During normal nematode development 131 somatic cells

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Unformatted text preview: ting apoptosis. During normal nematode development, 131 somatic cells out of a total of 1090 are eliminated by programmed cell death, yielding the 959 somatic cells in the adult worm. The death of these cells is highly specific, such that the same cells always die in developing embryos. Based on this developmental specificity, Robert Horvitz undertook a genetic analysis of cell death in C. elegans with the goal of identifying the genes responsible for these developmental cell deaths. In 1986 mutagenesis of C. elegans identified two genes, ced-3 and ced-4, that were required for developmental cell death. If either ced-3 or ced-4 was inactivated by mutaThis material cannot be copied, reproduced, manufactured, or disseminated in any form without express written permission from the publisher. © 2009 Sinauer Associates, Inc. 3 The term apoptosis is derived from the Greek word describing the falling of leaves from a tree or petals from a flower. It was coined to differentiate this form of programmed cell death from the accidental cell deaths caused by inflamma...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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