Cooper5e_Ch17

Embryonic stem cells would then be derived

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Unformatted text preview: ically identical to the recipient (who was the donor of the adult nucleus), so complications of immune rejection would be avoided. Adult somatic cell from patient Unfertilized egg Remove egg chromosomes Transfer nucleus to enucleated egg The possibility of therapeutic cloning provides the most general approach to treatment of the wide variety of devastating disorders for which stem cell transplantation therapy could be applied. However, although some success has been achieved in animal models, there remain major obstacles that would need to be overcome before therapeutic cloning could be applied to humans. Substantial improvements would be needed to overcome the low efficiency with which embryos are generated by somatic cell nuclear transfer. In addition, therapeutic cloning by somatic cell nuclear transfer raises ethical concerns, not only with respect to the possibility of cloning human beings (reproductive cloning ), but also with respect to the destruction of embryos that serve as the source of embryonic stem cells. These concerns may be alleviated by recent advances in reprogramming somatic cells to a pluripotent state resembling embryonic stem cells. Culture to early embryo Blas...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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