Cooper5e_Ch17

High dose chemotherapy hematopoietic stem cell

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Unformatted text preview: ation of hematopoietic system toxic to those normal tissues that are dependent on continual renewal by stem cells, such as blood, skin, hair, and the intestinal epithelium. The hematopoietic stem cells are among the most rapidly dividing cells of the body, so the toxic effects of anticancer drugs on these cells frequently limit the effectiveness of chemotherapy in cancer treatment. Hematopoietic stem cell transplantation provides an approach to bypassing this toxicity, thereby allowing the use of higher drug doses to treat the patient’s cancer more effectively. In this procedure, the patient is treated with high doses of chemotherapy that would normally not be tolerated because of toxic effects on the hematopoietic system (Figure 17.22). The potentially lethal damage is repaired, however, by transferring new hematopoietic stem cells (obtained either from bone marrow or peripheral blood) to the patient following completion of chemotherapy, so that a normal hematopoietic system is restored. In some cases, the stem cells are obtained from the patient prior to chemotherapy, stored, and then returned to the patient once chemotherapy is...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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