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If two thirds of the liver of a rat is surgically

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Unformatted text preview: ate the entire liver in a few days. Liver Removal of two-thirds of liver Proliferation of remaining cells Regeneration of liver The epithelial cells of some internal organs are also able to proliferate to replace damaged tissue. A striking example is provided by liver cells, which are normally arrested in the G0 phase of the cell cycle. However, if large numbers of liver cells are lost (e.g., by surgical removal of part of the liver), the remaining cells are stimulated to proliferate to replace the missing tissue ( Figure 17.16 ). For example, surgical removal of two-thirds of the liver of a rat is followed by rapid proliferation of the remaining cells, leading to regeneration of the entire liver within a few days. Stem Cells Most fully differentiated cells in adult animals, however, are no longer capable of cell division. Nonetheless, they can be replaced by the proliferation of a subpopulation of less differentiated self-renewing cells called stem cells that are present in most adult tissues. Because they retain the capacity to proliferate and replace differentiated cells throughout the lifetime of...
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