Importantly c elegans development included a very

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Unformatted text preview: was known. Importantly, C. elegans development included a very specific pattern of programmed cell deaths. In particular, John Sulston and H. Robert Horvitz reported in 1977 that the development of adult worms (consisting of 959 somatic cells) involved the programmed death of 131 cells out of 1090 that were initially produced. The same cells died in all embryos, indicating that the death of these cells was a normal event during development, with cell death being a specific developmental fate. It was also notable that all of these dying cells underwent a similar series of morphological changes, suggesting that these programmed cell deaths occurred by a common mechanism. Based on these considerations, Horvitz undertook a genetic analysis with the goal of characterizing the mechanism and regulation of programmed cell death during C. elegans development. In the experiments reported in this 1986 paper, Hilary Ellis and Horvitz identified two genes that were required for all of the programmed cell deaths that took place during development of the...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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