Cooper5e_Ch17

In 1997 ian wilmut and his colleagues initiated a new

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Unformatted text preview: mary epithelial cell that was transplanted into an unfertilized egg in place of the normal egg nucleus—a process called somatic cell nuclear transfer. It is interesting to note that this type of experiment was first carried out in frogs in the 1950s. The fact that it took over 40 years before it was successfully performed in mammals attests to the technical difficulty of the procedure. Since the initial success of Wilmut and his colleagues, transfer of nuclei from adult somatic cells into enucleated eggs has been used to create cloned offspring of a variety of mammalian species, including sheep, mice, pigs, cattle, goats, rabbits, and cats. However, cloning by somatic cell nuclear transfer in mammals remains an extremely inefficient procedure, such that only 1–3% of embryos generally give rise to live offspring. Animal cloning by somatic cell nuclear transfer, together with the properties of embryonic stem cells, opens the possibility of therapeutic cloning (Figure 17.26). In therapeutic cloning, a nucleus from an adult human cell would be transferred to an enucleated egg, which would then be used to produce an early embryo in cultu...
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This note was uploaded on 08/25/2009 for the course BIO 315 taught by Professor Steiner during the Spring '08 term at Kentucky.

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