Cooper5e_Ch17

In other circumstances however autophagy provides an

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Unformatted text preview: ay of cell death. Autophagic cell death does not require caspases and, rather than possessing the distinct morphological features of apoptosis, the dying cells are characterized by an accumulation of lysosomes. Autophagy has been shown to be an important pathway of programmed cell death during salivary gland development in Drosophila and to be induced by infection with some viruses. In addition, autophagy appears to provide an alternative pathway to cell death when apoptosis is blocked. For example, cells of mutant mice lacking Bak and Bax fail to undergo apoptosis in response to stimuli such as DNA damage, as expected since Bak and Bax are required for permeabilization of mitochondria (see Figure 17.8). However, the Bak/Bax-deficient cells die by autophagy instead, suggesting that autophagy may also be activated by cellular stress and provide an alternative to apoptosis under these conditions. It also appears that some forms of necrosis can be a programmed cellular response, rather than simply representing uncontrolled cell lysis as the result of an acute injury. In contrast to unregulated necrosis, these forms of regulated necrotic cell death are indu...
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