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Unformatted text preview: RMS
COMPANION WEBSITE Visit the website that accompanies The Cell (www.sinauer.com/cooper5e)
for animations, videos, quizzes, problems, and other review material.
programmed cell death, necrosis,
apoptosis PROGRAMMED CELL DEATH
The Events of Apoptosis: Programmed cell death plays a key role in both
the maintenance of adult tissues and embryonic development. In contrast to the accidental death of cells from an acute injury, programmed
cell death takes place by the active process of apoptosis. Apoptotic cells
and cell fragments are then efficiently removed by phagocytosis. Genes
responsible for the regulation and execution of apoptosis were initially
identified by genetic analysis of C. elegans.
See Website Animation 17.1 caspase, apoptosome Caspases: The Executioners of Apoptosis: The caspases are a family of
proteases that are the effectors of apoptosis. Caspases are classified as
either initiator or effector caspases, and both function in a cascade leading to cell death. In mammalian cells, the major initiator caspase is activated in a...
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